Preheat the Oven: Preheat your oven to 350°F (175°C).
Mix Dry Ingredients: In a large bowl, whisk together the flour, sugars, baking soda, baking powder, salt, and spices.
Combine Wet Ingredients: In another bowl, mix the pumpkin puree, oil, eggs (or applesauce), water, and vanilla extract until well combined.
Combine Mixtures: Pour the wet ingredients into the dry ingredients and stir until just combined. Do not overmix.
Prepare the Pan: Grease a 9x5-inch loaf pan and pour the batter into it.
Bake: Bake for 60 minutes, or until a toothpick inserted into the center comes out clean.
Cool: Allow the bread to cool in the pan for 10 minutes before transferring it to a wire rack to cool completely.